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KMID : 0829220110350040231
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Korean Journal of Oral and Maxillofacial Pathology
2011 Volume.35 No. 4 p.231 ~ p.237
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Anti-inflammatory Effect of Extracts from the Roots of Taraxacum Coreanum on Lipopolysacchaide - Induced Inflammation in BV2 Cells
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Lee Dong-Sung
Li Bin
Lee Yun-Jung
Chun Hyun-Ja
Ryu Il-Hwan
Jee Yeon-Ju
Chae Gwon-U
Kwon Yo-Seb
Shon Ji-Ue
Kang Hyun-Gyu
Lee Sung-Hee
An Ren-Bo
Lee Ho-Sub
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Abstract
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Taraxaci Herba has long been used in herbal medicine for their choleretic, anti-heumatic and diuretic properties. In the present study, we investigated the effects of origin plants of Taraxaci Herba, Taraxacum coreanum Nakai, as an anti-inflammatory agent in lipopolysaccharide(LPS)-induced microglial activation in BV2 cells. NNMBS273, the EtOH extracts of roots T. coreanum was examined for anti-neuronal inflammatory activity as new drug development. The roots of T. coreanum, showed the potent anti-neuroinflammatory effects on LPS-induced inflammation in microglial BV2 cells. The anti-inflammatory effects of NNMBS273, the EtOH extracts of roots T. coreanum was demonstrated by the suppression of pro-inflammatory mediators, including pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) and cytokines (tumor necrosis factor-α and interleukin-1β). These results suggest that the roots T. coreanum may be a promising candidate for the treatment of neurodegenerative diseases related to neuroinflammation.
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KEYWORD
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BV2, COX-2, iNOS, Neuroinflammation, Taraxacum coreanum
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